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Characteristics and Validation Techniques for PCA-Based Gene-Expression Signatures

Background. Many gene-expression signatures exist for describing the biological state of profiled tumors. Principal Component Analysis (PCA) can be used to summarize a gene signature into a single score. Our hypothesis is that gene signatures can be validated when applied to new datasets, using inhe...

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Detalhes bibliográficos
Publicado no:Int J Genomics
Main Authors: Berglund, Anders E., Welsh, Eric A., Eschrich, Steven A.
Formato: Artigo
Idioma:Inglês
Publicado em: Hindawi Publishing Corporation 2017
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5317117/
https://ncbi.nlm.nih.gov/pubmed/28265563
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1155/2017/2354564
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