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Targeted RP9 ablation and mutagenesis in mouse photoreceptor cells by CRISPR-Cas9
Precursor messenger RNA (Pre-mRNA) splicing is an essential biological process in eukaryotic cells. Genetic mutations in many spliceosome genes confer human eye diseases. Mutations in the pre-mRNA splicing factor, RP9 (also known as PAP1), predispose autosomal dominant retinitis pigmentosa (adRP) wi...
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| Publicado no: | Sci Rep |
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| Main Authors: | , , , , , , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
Nature Publishing Group
2017
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5317003/ https://ncbi.nlm.nih.gov/pubmed/28216641 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/srep43062 |
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