Mitochondrial ATP transporter depletion protects mice against liver steatosis and insulin resistance

Non-alcoholic fatty liver disease (NAFLD) is a common metabolic disorder in obese individuals. Adenine nucleotide translocase (ANT) exchanges ADP/ATP through the mitochondrial inner membrane, and Ant2 is the predominant isoform expressed in the liver. Here we demonstrate that targeted disruption of...

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Publicado no:Nat Commun
Main Authors: Cho, Joonseok, Zhang, Yujian, Park, Shi-Young, Joseph, Anna-Maria, Han, Chul, Park, Hyo-Jin, Kalavalapalli, Srilaxmi, Chun, Sung-Kook, Morgan, Drake, Kim, Jae-Sung, Someya, Shinichi, Mathews, Clayton E., Lee, Young Jae, Wohlgemuth, Stephanie E., Sunny, Nishanth E., Lee, Hui-Young, Choi, Cheol Soo, Shiratsuchi, Takayuki, Oh, S. Paul, Terada, Naohiro
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group 2017
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5316896/
https://ncbi.nlm.nih.gov/pubmed/28205519
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/ncomms14477
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