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MICU1 serves as a molecular gatekeeper to prevent in vivo mitochondrial calcium overload
MICU1 is a component of the mitochondrial calcium uniporter, a multiprotein complex that also includes MICU2, MCU, and EMRE. Here, we describe a mouse model of MICU1 deficiency. MICU1(−/−) mitochondria demonstrate altered calcium uptake and deletion of MICU1 results in significant, but not complete,...
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| Publicado no: | Cell Rep |
|---|---|
| Main Authors: | , , , , , , , , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2016
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5316484/ https://ncbi.nlm.nih.gov/pubmed/27477272 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.celrep.2016.07.011 |
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