Impact of phase I metabolism on uptake, oxidative stress and genotoxicity of the emerging mycotoxin alternariol and its monomethyl ether in esophageal cells

Studies on the genotoxicity of Alternaria mycotoxins focus primarily on the native compounds. Alternariol (AOH) and its methyl ether (AME) have been reported to represent substrates for cytochrome P450 enzymes, generating hydroxylated metabolites. The impact of these phase I metabolites on genotoxic...

Deskribapen osoa

Gorde:
Xehetasun bibliografikoak
Argitaratua izan da:Arch Toxicol
Egile Nagusiak: Tiessen, Christine, Ellmer, Doris, Mikula, Hannes, Pahlke, Gudrun, Warth, Benedikt, Gehrke, Helge, Zimmermann, Kristin, Heiss, Elke, Fröhlich, Johannes, Marko, Doris
Formatua: Artigo
Hizkuntza:Inglês
Argitaratua: Springer Berlin Heidelberg 2016
Gaiak:
Toxicokinetics and Metabolism
Sarrera elektronikoa:https://ncbi.nlm.nih.gov/pmc/articles/PMC5316404/
https://ncbi.nlm.nih.gov/pubmed/27422292
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s00204-016-1801-0
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