Impact of phase I metabolism on uptake, oxidative stress and genotoxicity of the emerging mycotoxin alternariol and its monomethyl ether in esophageal cells

Studies on the genotoxicity of Alternaria mycotoxins focus primarily on the native compounds. Alternariol (AOH) and its methyl ether (AME) have been reported to represent substrates for cytochrome P450 enzymes, generating hydroxylated metabolites. The impact of these phase I metabolites on genotoxic...

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Detalhes bibliográficos
Publicado no:Arch Toxicol
Main Authors: Tiessen, Christine, Ellmer, Doris, Mikula, Hannes, Pahlke, Gudrun, Warth, Benedikt, Gehrke, Helge, Zimmermann, Kristin, Heiss, Elke, Fröhlich, Johannes, Marko, Doris
Formato: Artigo
Idioma:Inglês
Publicado em: Springer Berlin Heidelberg 2016
Assuntos:
Toxicokinetics and Metabolism
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5316404/
https://ncbi.nlm.nih.gov/pubmed/27422292
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s00204-016-1801-0
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