Pharmacokinetic analysis and drug delivery efficiency of the focused ultrasound-induced blood-brain barrier opening in non-human primates

PURPOSE: Focused Ultrasound (FUS) in conjunction with systemically administered microbubbles has been shown to open the Blood-Brain Barrier (BBB) locally, non-invasively and reversibly in rodents and non-human primates (NHP), suggesting the immense potential of this technique. The objective of this...

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Pubblicato in:Magn Reson Imaging
Autori principali: Samiotaki, Gesthimani, Karakatsani, Maria Eleni, Buch, Amanda, Papadopoulos, Stephanos, Wu, Shih Ying, Jambawalikar, Sachin, Konofagou, Elisa E.
Natura: Artigo
Lingua:Inglês
Pubblicazione: 2016
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Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC5316348/
https://ncbi.nlm.nih.gov/pubmed/27916657
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.mri.2016.11.023
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