Uniform low-level dystrophin expression in the heart partially preserved cardiac function in an aged mouse model of Duchenne cardiomyopathy

Dystrophin deficiency results in Duchenne cardiomyopathy, a primary cause of death in Duchenne muscular dystrophy (DMD). Gene therapy has shown great promise in ameliorating the cardiac phenotype in mouse models of DMD. However, it is not completely clear how much dystrophin is required to treat dys...

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Gepubliceerd in:J Mol Cell Cardiol
Hoofdauteurs: Wasala, Nalinda B., Yue, Yongping, Vance, Jenna, Duan, Dongsheng
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: 2016
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Article
Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5316315/
https://ncbi.nlm.nih.gov/pubmed/27908661
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.yjmcc.2016.11.011
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