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Clinical Pharmacokinetics and Pharmacodynamics of Afatinib
Afatinib is an oral, irreversible ErbB family blocker that covalently binds to the kinase domains of epidermal growth factor receptor (EGFR), human EGFRs (HER) 2, and HER4, resulting in irreversible inhibition of tyrosine kinase autophosphorylation. Studies in healthy volunteers and patients with ad...
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| Publicado no: | Clin Pharmacokinet |
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| Main Authors: | , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
Springer International Publishing
2016
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5315738/ https://ncbi.nlm.nih.gov/pubmed/27470518 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s40262-016-0440-1 |
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