Therapeutic inhibition of the MDM2-p53 interaction prevents recurrence of adenoid cystic carcinomas

PURPOSE: Conventional chemotherapy has modest efficacy in advanced adenoid cystic carcinomas (ACC). Tumor recurrence is a major challenge in the management of ACC patients. Here, we evaluated the anti-tumor effect of a novel small molecule inhibitor of the MDM2-p53 interaction (MI-773) combined with...

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Bibliografiska uppgifter
I publikationen:Clin Cancer Res
Huvudupphovsmän: Nör, Felipe, Warner, Kristy A., Zhang, Zhaocheng, Acasigua, Gerson A., Pearson, Alexander T., Kerk, Samuel A., Helman, Joseph, Filho, Manoel Sant’Ana, Wang, Shaomeng, Nör, Jacques E.
Materialtyp: Artigo
Språk:Inglês
Publicerad: 2016
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Article
Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC5315632/
https://ncbi.nlm.nih.gov/pubmed/27550999
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/1078-0432.CCR-16-1235
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