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Optimality principles reveal a complex interplay of intermediate toxicity and kinetic efficiency in the regulation of prokaryotic metabolism

A precise and rapid adjustment of fluxes through metabolic pathways is crucial for organisms to prevail in changing environmental conditions. Based on this reasoning, many guiding principles that govern the evolution of metabolic networks and their regulation have been uncovered. To this end, method...

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Publicat a:PLoS Comput Biol
Autors principals: Ewald, Jan, Bartl, Martin, Dandekar, Thomas, Kaleta, Christoph
Format: Artigo
Idioma:Inglês
Publicat: Public Library of Science 2017
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Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC5315294/
https://ncbi.nlm.nih.gov/pubmed/28212377
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pcbi.1005371
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