Minimum-noise production of translation factor eIF4G maps to a mechanistically determined optimal rate control window for protein synthesis

Gene expression noise influences organism evolution and fitness. The mechanisms determining the relationship between stochasticity and the functional role of translation machinery components are critical to viability. eIF4G is an essential translation factor that exerts strong control over protein s...

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Bibliographic Details
Published in:Nucleic Acids Res
Main Authors: Meng, Xiang, Firczuk, Helena, Pietroni, Paola, Westbrook, Richard, Dacheux, Estelle, Mendes, Pedro, McCarthy, John E.G.
Format: Artigo
Language:Inglês
Published: Oxford University Press 2017
Subjects:
Synthetic Biology and Bioengineering
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC5314777/
https://ncbi.nlm.nih.gov/pubmed/27928055
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gkw1194
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