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The eukaryotic mRNA decapping protein Dcp1 interacts physically and functionally with the eIF4F translation initiation complex

Dcp1 plays a key role in the mRNA decay process in Saccharomyces cerevisiae, cleaving off the 5′ cap to leave an end susceptible to exonucleolytic degradation. The eukaryotic initiation factor complex eIF4F, which in yeast contains the core components eIF4E and eIF4G, uses the cap as a binding site,...

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Detalhes bibliográficos
Main Authors: Vilela, Cristina, Velasco, Carmen, Ptushkina, Marina, McCarthy, John E.G.
Formato: Artigo
Idioma:Inglês
Publicado em: Oxford University Press 2000
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC302023/
https://ncbi.nlm.nih.gov/pubmed/10944120
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/emboj/19.16.4372
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