Activating Akt1 mutations alter DNA double strand break repair and radiosensitivity

The survival kinase Akt has clinical relevance to radioresistance. However, its contributions to the DNA damage response, DNA double strand break (DSB) repair and apoptosis remain poorly defined and often contradictory. We used a genetic approach to explore the consequences of genetic alterations of...

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Publicado en:Sci Rep
Autores principales: Oeck, S., Al-Refae, K., Riffkin, H., Wiel, G., Handrick, R., Klein, D., Iliakis, G., Jendrossek, V.
Formato: Artigo
Lenguaje:Inglês
Publicado: Nature Publishing Group 2017
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Article
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC5314324/
https://ncbi.nlm.nih.gov/pubmed/28209968
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/srep42700
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