Structural and Kinetic Studies of the Human Nudix Hydrolase MTH1 Reveal the Mechanism for Its Broad Substrate Specificity

The human MutT homolog 1 (hMTH1, human NUDT1) hydrolyzes oxidatively damaged nucleoside triphosphates and is the main enzyme responsible for nucleotide sanitization. hMTH1 recently has received attention as an anticancer target because hMTH1 blockade leads to accumulation of oxidized nucleotides in...

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Tallennettuna:
Bibliografiset tiedot
Julkaisussa:J Biol Chem
Päätekijät: Waz, Shaimaa, Nakamura, Teruya, Hirata, Keisuke, Koga-Ogawa, Yukari, Chirifu, Mami, Arimori, Takao, Tamada, Taro, Ikemizu, Shinji, Nakabeppu, Yusaku, Yamagata, Yuriko
Aineistotyyppi: Artigo
Kieli:Inglês
Julkaistu: American Society for Biochemistry and Molecular Biology 2017
Aiheet:
Enzymology
Linkit:https://ncbi.nlm.nih.gov/pmc/articles/PMC5314174/
https://ncbi.nlm.nih.gov/pubmed/28035004
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M116.749713
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