Pigment epithelium-derived factor, a non-inhibitory serine protease inhibitor, is renoprotective by inhibiting the Wnt pathway

Pigment epithelium-derived factor (PEDF) expression is down- regulated in the kidneys of diabetic rats and delivery of PEDF suppressed renal fibrotic factors in these animals. PEDF has multiple functions including anti-angiogenic, anti-inflammatory and anti-fibrotic activities. Since the mechanism u...

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Udgivet i:Kidney Int
Main Authors: He, Xuemin, Cheng, Rui, Park, Kyoungmin, Benyajati, Siribhinya, Moiseyev, Gennadiy, Sun, Chengyi, Olson, Lorin, Yang, Yanhui, Eby, Bonnie K, Lau, Kai, Ma, Jian-xing
Format: Artigo
Sprog:Inglês
Udgivet: 2016
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5313326/
https://ncbi.nlm.nih.gov/pubmed/27914705
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.kint.2016.09.036
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