Chemosensitive relapse in small cell lung cancer proceeds through an EZH2-SLFN11 axis

Small cell lung cancer is initially highly responsive to cisplatin and etoposide but in almost every case becomes rapidly chemoresistant, leading to death within one year. We modeled acquired chemoresistance in vivo using a series of patient-derived xenografts to generate paired chemosensitive and c...

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Udgivet i:Cancer Cell
Main Authors: Gardner, Eric E., Lok, Benjamin H., Schneeberger, Valentina E., Desmeules, Patrice, Miles, Linde A., Arnold, Paige K., Ni, Andy, Khodos, Inna, de Stanchina, Elisa, Nguyen, Thuyen, Sage, Julien, Campbell, John E., Ribich, Scott, Rekhtman, Natasha, Dowlati, Afshin, Massion, Pierre P., Rudin, Charles M., Poirier, John T.
Format: Artigo
Sprog:Inglês
Udgivet: 2017
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5313262/
https://ncbi.nlm.nih.gov/pubmed/28196596
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.ccell.2017.01.006
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