HLA-DQ β1 alleles associated with Epstein-Barr virus (EBV) infectivity and EBV gp42 binding to cells

Epstein-Barr virus (EBV) infects B cells and ~95% of adults are infected. EBV glycoprotein gp42 is essential for entry of virus into B cells. EBV gp42 binds to the β1 chain of HLA-DQ, -DR, and -DP on B cells, and uses these molecules for infection. To investigate if certain HLA-DQ alleles are associ...

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Détails bibliographiques
Publié dans:JCI Insight
Auteurs principaux: Li, Qingxue, Bu, Wei, Gabriel, Erin, Aguilar, Fiona, Hoshino, Yo, Miyadera, Hiroko, Hess, Christoph, Hornung, Ronald L., Roy, Amitava, Cohen, Jeffrey I.
Format: Artigo
Langue:Inglês
Publié: American Society for Clinical Investigation 2017
Sujets:
Research Article
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC5313076/
https://ncbi.nlm.nih.gov/pubmed/28239644
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/jci.insight.85687
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