Tissue-resident macrophages can contain replication-competent virus in antiretroviral-naive, SIV-infected Asian macaques

SIV DNA can be detected in lymphoid tissue–resident macrophages of chronically SIV-infected Asian macaques. These macrophages also contain evidence of recently phagocytosed SIV-infected CD4(+) T cells. Here, we examine whether these macrophages contain replication-competent virus, whether viral DNA...

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Udgivet i:JCI Insight
Main Authors: DiNapoli, Sarah R., Ortiz, Alexandra M., Wu, Fan, Matsuda, Kenta, Twigg, Homer L., Hirsch, Vanessa M., Knox, Kenneth, Brenchley, Jason M.
Format: Artigo
Sprog:Inglês
Udgivet: American Society for Clinical Investigation 2017
Fag:
Research Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5313072/
https://ncbi.nlm.nih.gov/pubmed/28239657
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/jci.insight.91214
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