Legumain Regulates Differentiation Fate of Human Bone Marrow Stromal Cells and Is Altered in Postmenopausal Osteoporosis

Secreted factors are a key component of stem cell niche and their dysregulation compromises stem cell function. Legumain is a secreted cysteine protease involved in diverse biological processes. Here, we demonstrate that legumain regulates lineage commitment of human bone marrow stromal cells and th...

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Veröffentlicht in:Stem Cell Reports
Hauptverfasser: Jafari, Abbas, Qanie, Diyako, Andersen, Thomas L., Zhang, Yuxi, Chen, Li, Postert, Benno, Parsons, Stuart, Ditzel, Nicholas, Khosla, Sundeep, Johansen, Harald Thidemann, Kjærsgaard-Andersen, Per, Delaisse, Jean-Marie, Abdallah, Basem M., Hesselson, Daniel, Solberg, Rigmor, Kassem, Moustapha
Format: Artigo
Sprache:Inglês
Veröffentlicht: Elsevier 2017
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5312427/
https://ncbi.nlm.nih.gov/pubmed/28162997
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.stemcr.2017.01.003
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