An oncolytic adenovirus that expresses the HAb18 and interleukin 24 genes exhibits enhanced antitumor activity in hepatocellular carcinoma cells

Hepatocellular carcinoma (HCC) is characterized by alterations in multiple genes. High expression of CD147 on the surface of HCC cells promotes proliferation. The monoclonal antibody HAb18 recognizes CD147. We constructed an oncolytic adenoviral vector to express HAb18 (ZD55-HAb18) in HCC cells. Int...

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Udgivet i:Oncotarget
Main Authors: Yuan, Sujing, Fang, Xianlong, Xu, Yanni, Ni, Aimin, Liu, Xin-Yuan, Chu, Liang
Format: Artigo
Sprog:Inglês
Udgivet: Impact Journals LLC 2016
Fag:
Research Paper
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5312398/
https://ncbi.nlm.nih.gov/pubmed/27528029
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.18632/oncotarget.11134
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