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RAD51 inhibition in triple negative breast cancer cells is challenged by compensatory survival signaling and requires rational combination therapy

The molecular rationale to induce synthetic lethality, by targeting defective homologous recombination repair in triple negative breast cancer (TNBC), has proven to have several shortcomings. Not meeting the expected minimal outcomes in clinical trials has highlighted common clinical resistance mech...

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Detalhes bibliográficos
Publicado no:Oncotarget
Main Authors: Wiegmans, Adrian P., Miranda, Mariska, Wen, Shu Wen, Al-Ejeh, Fares, Möller, Andreas
Formato: Artigo
Idioma:Inglês
Publicado em: Impact Journals LLC 2016
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5312370/
https://ncbi.nlm.nih.gov/pubmed/27507046
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.18632/oncotarget.11065
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