Hypoxia-induced angiotensin II by the lactate-chymase-dependent mechanism mediates radioresistance of hypoxic tumor cells

The renin-angiotensin system (RAS) is a principal determinant of arterial blood pressure and fluid and electrolyte balance. RAS component dysregulation was recently found in some malignancies and correlated with poor patient outcomes. However, the exact mechanism of local RAS activation in tumors is...

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Vydáno v:Sci Rep
Hlavní autoři: Xie, Guozhu, Liu, Ying, Yao, Qiwei, Zheng, Rong, Zhang, Lanfang, Lin, Jie, Guo, Zhaoze, Du, Shasha, Ren, Chen, Yuan, Quan, Yuan, Yawei
Médium: Artigo
Jazyk:Inglês
Vydáno: Nature Publishing Group 2017
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Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC5311966/
https://ncbi.nlm.nih.gov/pubmed/28205588
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/srep42396
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