TAT-ODD-p53 enhances the radiosensitivity of hypoxic breast cancer cells by inhibiting Parkin-mediated mitophagy

Radiation therapy has an important role in the treatment of breast cancer. Dysfunction p53 and hypoxia are typical biological characteristics of breast cancer that constitute barriers to the efficacy of radiotherapy. Mitophagy plays a protective role in cellular homeostasis under hypoxic conditions,...

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Vydáno v:Oncotarget
Hlavní autoři: Zheng, Rong, Yao, Qiwei, Xie, Guozhu, Du, Shasha, Ren, Chen, Wang, Yuxia, Yuan, Yawei
Médium: Artigo
Jazyk:Inglês
Vydáno: Impact Journals LLC 2015
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Research Paper
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC4627318/
https://ncbi.nlm.nih.gov/pubmed/26025927
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