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TAT-ODD-p53 enhances the radiosensitivity of hypoxic breast cancer cells by inhibiting Parkin-mediated mitophagy

Radiation therapy has an important role in the treatment of breast cancer. Dysfunction p53 and hypoxia are typical biological characteristics of breast cancer that constitute barriers to the efficacy of radiotherapy. Mitophagy plays a protective role in cellular homeostasis under hypoxic conditions,...

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Détails bibliographiques
Publié dans:Oncotarget
Auteurs principaux: Zheng, Rong, Yao, Qiwei, Xie, Guozhu, Du, Shasha, Ren, Chen, Wang, Yuxia, Yuan, Yawei
Format: Artigo
Langue:Inglês
Publié: Impact Journals LLC 2015
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Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC4627318/
https://ncbi.nlm.nih.gov/pubmed/26025927
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