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Activity of erlotinib when dosed below maximum tolerable dose for EGFR-mutant lung cancer: implications for targeted therapy development

BACKGROUND: Erlotinib is a standard first-line therapy for metastatic non-small-cell lung cancers (NSCLC) with epidermal growth factor receptor (EGFR) mutations. The recommended dose of 150mg daily is the maximum tolerated dose (MTD). Little clinical data is available regarding its efficacy at doses...

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Bibliografski detalji
Izdano u:Cancer
Glavni autori: Lampson, Benjamin L., Nishino, Mizuki, Dahlberg, Suzanne E., Paul, Danie, Santos, Abigail A., Jänne MD, Pasi A., Oxnard, Geoffrey R.
Format: Artigo
Jezik:Inglês
Izdano: 2016
Teme:
Online pristup:https://ncbi.nlm.nih.gov/pmc/articles/PMC5311035/
https://ncbi.nlm.nih.gov/pubmed/27525836
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/cncr.30270
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