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Activity of erlotinib when dosed below maximum tolerable dose for EGFR-mutant lung cancer: implications for targeted therapy development

BACKGROUND: Erlotinib is a standard first-line therapy for metastatic non-small-cell lung cancers (NSCLC) with epidermal growth factor receptor (EGFR) mutations. The recommended dose of 150mg daily is the maximum tolerated dose (MTD). Little clinical data is available regarding its efficacy at doses...

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Bibliografiske detaljer
Udgivet i:Cancer
Main Authors: Lampson, Benjamin L., Nishino, Mizuki, Dahlberg, Suzanne E., Paul, Danie, Santos, Abigail A., Jänne MD, Pasi A., Oxnard, Geoffrey R.
Format: Artigo
Sprog:Inglês
Udgivet: 2016
Fag:
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5311035/
https://ncbi.nlm.nih.gov/pubmed/27525836
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/cncr.30270
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