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Activity of erlotinib when dosed below maximum tolerable dose for EGFR-mutant lung cancer: implications for targeted therapy development

BACKGROUND: Erlotinib is a standard first-line therapy for metastatic non-small-cell lung cancers (NSCLC) with epidermal growth factor receptor (EGFR) mutations. The recommended dose of 150mg daily is the maximum tolerated dose (MTD). Little clinical data is available regarding its efficacy at doses...

Disgrifiad llawn

Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Cyhoeddwyd yn:Cancer
Prif Awduron: Lampson, Benjamin L., Nishino, Mizuki, Dahlberg, Suzanne E., Paul, Danie, Santos, Abigail A., Jänne MD, Pasi A., Oxnard, Geoffrey R.
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: 2016
Pynciau:
Mynediad Ar-lein:https://ncbi.nlm.nih.gov/pmc/articles/PMC5311035/
https://ncbi.nlm.nih.gov/pubmed/27525836
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/cncr.30270
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