The FcμR Limits Tonic BCR Signaling by Regulating IgM-BCR Expression

The IgM Fc receptor (FcμR), originally cloned as “Fas-apoptosis inhibitory molecule (FAIM3/TOSO)” can function as a cell surface receptor for secreted IgM on a variety of cell types. We report that FcμR also is expressed in the trans-Golgi network of developing B cells, where it constrains IgM- but...

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Gepubliceerd in:Nat Immunol
Hoofdauteurs: Nguyen, Trang T. T., Kläsener, Kathrin, Zürn, Christa, Castillo, Patricia A., Brust-Mascher, Ingrid, Imai, Denise M., Bevins, Charles L., Reardon, Colin, Reth, Michael, Baumgarth, Nicole
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: 2017
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Article
Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5310993/
https://ncbi.nlm.nih.gov/pubmed/28135254
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/ni.3677
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