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Chemical proteomics reveals ADP-ribosylation of small GTPases during oxidative stress
ADP-ribosylation is a posttranslational modification involved in cellular homeostasis and stress, but has been challenging to analyze biochemically. To facilitate the detection of ADP-ribosylated proteins, we show that an alkyne-adenosine analog, N(6)-propargyladenosine (N(6)pA), is metabolically in...
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| Veröffentlicht in: | Nat Chem Biol |
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| Hauptverfasser: | , , , |
| Format: | Artigo |
| Sprache: | Inglês |
| Veröffentlicht: |
2017
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| Schlagworte: | |
| Online Zugang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5310985/ https://ncbi.nlm.nih.gov/pubmed/28092360 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/nchembio.2280 |
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