Transcriptional regulation of PNPLA3 and its impact on susceptibility to nonalcoholic fatty liver Disease (NAFLD) in humans

The increased expression of PNPLA3(148M) leads to hepatosteatosis in mice. This study aims to investigate the genetic control of hepatic PNPLA3 transcription and to explore its impact on NAFLD risk in humans. Through a locus-wide expression quantitative trait loci (eQTL) mapping in two human liver s...

Disgrifiad llawn

Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Cyhoeddwyd yn:Aging (Albany NY)
Prif Awduron: Liu, Wanqing, Anstee, Quentin M, Wang, Xiaoliang, Gawrieh, Samer, Gamazon, Eric R., Athinarayanan, Shaminie, Liu, Yang-Lin, Darlay, Rebecca, Cordell, Heather J, Daly, Ann K, Day, Chris P, Chalasani, Naga
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: Impact Journals LLC 2016
Pynciau:
Research Paper
Mynediad Ar-lein:https://ncbi.nlm.nih.gov/pmc/articles/PMC5310654/
https://ncbi.nlm.nih.gov/pubmed/27744419
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.18632/aging.101067
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