Transcriptional regulation of PNPLA3 and its impact on susceptibility to nonalcoholic fatty liver Disease (NAFLD) in humans

The increased expression of PNPLA3(148M) leads to hepatosteatosis in mice. This study aims to investigate the genetic control of hepatic PNPLA3 transcription and to explore its impact on NAFLD risk in humans. Through a locus-wide expression quantitative trait loci (eQTL) mapping in two human liver s...

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Detalhes bibliográficos
Publicado no:Aging (Albany NY)
Main Authors: Liu, Wanqing, Anstee, Quentin M, Wang, Xiaoliang, Gawrieh, Samer, Gamazon, Eric R., Athinarayanan, Shaminie, Liu, Yang-Lin, Darlay, Rebecca, Cordell, Heather J, Daly, Ann K, Day, Chris P, Chalasani, Naga
Formato: Artigo
Idioma:Inglês
Publicado em: Impact Journals LLC 2016
Assuntos:
Research Paper
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5310654/
https://ncbi.nlm.nih.gov/pubmed/27744419
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.18632/aging.101067
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