A novel cytoprotective peptide protects mesenchymal stem cells against mitochondrial dysfunction and apoptosis induced by starvation via Nrf2/Sirt3/FoxO3a pathway

BACKGROUND: Mesenchymal stem cell (MSC) has been widely explored in the past decade as a cell-based treatment for various diseases. However, poor survival of adaptively transferred MSCs limits their clinical therapeutic potentials, which is largely ascribed to the nutrient starvation. In this study,...

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Publicat a:J Transl Med
Autors principals: Wang, Shuo, Zhang, Chao, Niyazi, Sidikejiang, Zheng, Long, Li, Jiawei, Zhang, Weitao, Xu, Ming, Rong, Ruiming, Yang, Cheng, Zhu, Tongyu
Format: Artigo
Idioma:Inglês
Publicat: BioMed Central 2017
Matèries:
Research
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC5309997/
https://ncbi.nlm.nih.gov/pubmed/28202079
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s12967-017-1144-5
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