Natural amines inhibit activation of human plasmacytoid dendritic cells through CXCR4 engagement

Plasmacytoid dendritic cells (pDC) are specialized in secretion of type I interferon in response to pathogens. Here we show that natural monoamines and synthetic amines inhibit pDC activation by RNA viruses. Furthermore, a synthetic analogue of histamine reduces type I interferon production in a mou...

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Detalhes bibliográficos
Publicado no:Nat Commun
Main Authors: Smith, Nikaïa, Pietrancosta, Nicolas, Davidson, Sophia, Dutrieux, Jacques, Chauveau, Lise, Cutolo, Pasquale, Dy, Michel, Scott-Algara, Daniel, Manoury, Bénédicte, Zirafi, Onofrio, McCort-Tranchepain, Isabelle, Durroux, Thierry, Bachelerie, Françoise, Schwartz, Olivier, Münch, Jan, Wack, Andreas, Nisole, Sébastien, Herbeuval, Jean-Philippe
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group 2017
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5309800/
https://ncbi.nlm.nih.gov/pubmed/28181493
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/ncomms14253
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