MicroRNA-155 Controls Exosome Synthesis and Promotes Gemcitabine Resistance in Pancreatic Ductal Adenocarcinoma

The cancer drug gemcitabine (GEM) is a key drug for treating pancreatic ductal adenocarcinoma (PDAC), but PDAC cells develop chemoresistance after long-term administration. Since the tolerance was immediately spread to every PDAC tissue in a patient, it is assumed that some certain efficient mechani...

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Udgivet i:Sci Rep
Main Authors: Mikamori, Manabu, Yamada, Daisaku, Eguchi, Hidetoshi, Hasegawa, Shinichiro, Kishimoto, Tomoya, Tomimaru, Yoshito, Asaoka, Tadafumi, Noda, Takehiro, Wada, Hiroshi, Kawamoto, Koichi, Gotoh, Kunihito, Takeda, Yutaka, Tanemura, Masahiro, Mori, Masaki, Doki, Yuichiro
Format: Artigo
Sprog:Inglês
Udgivet: Nature Publishing Group 2017
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5309735/
https://ncbi.nlm.nih.gov/pubmed/28198398
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/srep42339
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