Natural nitration of CXCL12 reduces its signaling capacity and chemotactic activity in vitro and abrogates intra-articular lymphocyte recruitment in vivo

The chemokine CXCL12/stromal cell-derived factor-1 is important for leukocyte migration to lymphoid organs and inflamed tissues and stimulates tumor development. In vitro, CXCL12 activity through CXCR4 is abolished by proteolytic processing. However, limited information is available on in vivo effec...

पूर्ण विवरण

में बचाया:
ग्रंथसूची विवरण
में प्रकाशित:Oncotarget
मुख्य लेखकों: Janssens, Rik, Mortier, Anneleen, Boff, Daiane, Vanheule, Vincent, Gouwy, Mieke, Franck, Charlotte, Larsen, Olav, Rosenkilde, Mette M., Van Damme, Jo, Amaral, Flávio A., Teixeira, Mauro M., Struyf, Sofie, Proost, Paul
स्वरूप: Artigo
भाषा:Inglês
प्रकाशित: Impact Journals LLC 2016
विषय:
Research Paper
ऑनलाइन पहुंच:https://ncbi.nlm.nih.gov/pmc/articles/PMC5308738/
https://ncbi.nlm.nih.gov/pubmed/27566567
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.18632/oncotarget.11516
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