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miR182 activates the Ras–MEK–ERK pathway in human oral cavity squamous cell carcinoma by suppressing RASA1 and SPRED1

PURPOSE: The constitutive activation of the Ras–MEK–ERK signaling pathway in oral cavity squamous cell carcinoma (OSCC) has been found to be tightly controlled at multiple levels under physiological conditions. RASA1 and SPRED1 are two important negative regulators of this pathway, but the exact reg...

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Bibliografiske detaljer
Udgivet i:Onco Targets Ther
Main Authors: Wang, Jinhui, Wang, Wei, Li, Jichen, Wu, Liji, Song, Mei, Meng, Qinggang
Format: Artigo
Sprog:Inglês
Udgivet: Dove Medical Press 2017
Fag:
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5308578/
https://ncbi.nlm.nih.gov/pubmed/28223824
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.2147/OTT.S121864
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