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Direct proximity tagging of small molecule protein targets using an engineered NEDD8 ligase
Identifying the protein targets of bioactive small molecules remains a major problem in the discovery of new chemical probes and therapeutics. While activity-based probes and photo-crosslinkers have had success in identifying protein targets of small molecules, each technique has limitations. Here w...
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| Publicado no: | J Am Chem Soc |
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| Main Authors: | , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2016
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5308480/ https://ncbi.nlm.nih.gov/pubmed/27626304 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/jacs.6b06828 |
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