Phosphorylation-dependent regulation of ALDH1A1 by Aurora kinase A: insights on their synergistic relationship in pancreatic cancer

BACKGROUND: Epithelial-to-mesenchymal transition (EMT) and cancer stem cell (CSC) formation are key underlying causes that promote extensive metastasis, drug resistance, and tumor recurrence in highly lethal pancreatic cancer. The mechanisms leading to EMT and CSC phenotypes are not fully understood...

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Udgivet i:BMC Biol
Main Authors: Wang, Jing, Nikhil, Kumar, Viccaro, Keith, Chang, Lei, White, Jacoba, Shah, Kavita
Format: Artigo
Sprog:Inglês
Udgivet: BioMed Central 2017
Fag:
Research Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5307883/
https://ncbi.nlm.nih.gov/pubmed/28193222
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s12915-016-0335-5
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