Enhanced expression of Vastatin inhibits angiogenesis and prolongs survival in murine orthotopic glioblastoma model

BACKGROUND: Antiangiogenic therapies are considered promising for the treatment of glioblastoma (GB). The non-collagenous C-terminal globular NC1 domain of type VIII collagen a1 chain, Vastatin, is an endogenous antiangiogenic polypeptide. Sustained enhanced expression of Vastatin was shown to inhib...

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Publicado en:BMC Cancer
Autores principales: Li, Yi, Li, Jun, Woo, Yat Ming, Shen, Zan, Yao, Hong, Cai, Yijun, Lin, Marie Chia-mi, Poon, Wai Sang
Formato: Artigo
Lenguaje:Inglês
Publicado: BioMed Central 2017
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Research Article
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC5307880/
https://ncbi.nlm.nih.gov/pubmed/28193190
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s12885-017-3125-8
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