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Mechanism of catalysis, E2 recognition, and autoinhibition for the IpaH family of bacterial E3 ubiquitin ligases

IpaH enzymes are secreted bacterial effectors that function within host cells as E3 ubiquitin (Ub) ligases. Catalytic activity is imparted by a conserved novel E3 ligase (NEL) domain that is unique to Gram-negative pathogens and whose activity is repressed by a flanking substrate-binding leucine-ric...

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Dades bibliogràfiques
Publicat a:Proc Natl Acad Sci U S A
Autors principals: Keszei, Alexander F. A., Sicheri, Frank
Format: Artigo
Idioma:Inglês
Publicat: National Academy of Sciences 2017
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Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC5307447/
https://ncbi.nlm.nih.gov/pubmed/28115697
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1611595114
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