Smoothened is a poor prognosis factor and a potential therapeutic target in glioma

Malignant gliomas are associated with a high mortality rate. Thus, there is an urgent need for the development of novel targeted therapeutics. Aberrant Hedgehog signaling has been directly linked to glioma. GDC-0449 is a novel small molecule inhibitor of Hedgehog signaling that blocks the activity o...

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Vydáno v:Sci Rep
Hlavní autoři: Tu, Yiming, Niu, Mingshan, Xie, Peng, Yue, Chenglong, Liu, Ning, Qi, Zhenglei, Gao, Shangfeng, Liu, Hongmei, Shi, Qiong, Yu, Rutong, Liu, Xuejiao
Médium: Artigo
Jazyk:Inglês
Vydáno: Nature Publishing Group 2017
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Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC5307388/
https://ncbi.nlm.nih.gov/pubmed/28195165
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/srep42630
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