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Smoothened is a poor prognosis factor and a potential therapeutic target in glioma
Malignant gliomas are associated with a high mortality rate. Thus, there is an urgent need for the development of novel targeted therapeutics. Aberrant Hedgehog signaling has been directly linked to glioma. GDC-0449 is a novel small molecule inhibitor of Hedgehog signaling that blocks the activity o...
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| Publicado en: | Sci Rep |
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| Autores principales: | , , , , , , , , , , |
| Formato: | Artigo |
| Lenguaje: | Inglês |
| Publicado: |
Nature Publishing Group
2017
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| Materias: | |
| Acceso en línea: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5307388/ https://ncbi.nlm.nih.gov/pubmed/28195165 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/srep42630 |
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