Sustained activation of protein kinase C is essential to HL-60 cell differentiation to macrophage.

Although a single dose of phorbol 12-myristate 13-acetate (PMA) allowed HL-60 cells to differentiate to macrophages, a single dose of membrane-permeant diacylglycerol (DAG), 1,2-dioctanoylglycerol (1,2-DiC8), was normally insufficient to differentiate these cells. These cells metabolized 1,2-DiC8 ve...

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Main Authors: Aihara, H, Asaoka, Y, Yoshida, K, Nishizuka, Y
Format: Artigo
Jezik:Inglês
Izdano: 1991
Teme:
Research Article
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC53073/
https://ncbi.nlm.nih.gov/pubmed/1763021
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