Sustained activation of protein kinase C is essential to HL-60 cell differentiation to macrophage.
Although a single dose of phorbol 12-myristate 13-acetate (PMA) allowed HL-60 cells to differentiate to macrophages, a single dose of membrane-permeant diacylglycerol (DAG), 1,2-dioctanoylglycerol (1,2-DiC8), was normally insufficient to differentiate these cells. These cells metabolized 1,2-DiC8 ve...
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| Publicado no: | Proc Natl Acad Sci U S A |
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| Principais autores: | , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
National Academy of Sciences
1991
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC53073/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/1763021/ https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.88.24.11062 |
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