Selective expansion of high functional avidity memory CD8 T cell clonotypes during hepatitis C virus reinfection and clearance

The dynamics of the memory CD8 T cell receptor (TCR) repertoire upon virus re-exposure and factors governing the selection of TCR clonotypes conferring protective immunity in real life settings are poorly understood. Here, we examined the dynamics and functionality of the virus-specific memory CD8 T...

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Bibliografiske detaljer
Udgivet i:PLoS Pathog
Main Authors: Abdel-Hakeem, Mohamed S., Boisvert, Maude, Bruneau, Julie, Soudeyns, Hugo, Shoukry, Naglaa H.
Format: Artigo
Sprog:Inglês
Udgivet: Public Library of Science 2017
Fag:
Research Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5305272/
https://ncbi.nlm.nih.gov/pubmed/28146579
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.ppat.1006191
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