Early Interferon Therapy for Hepatitis C Virus Infection Rescues Polyfunctional, Long-Lived CD8(+) Memory T Cells

The majority of acute hepatitis C virus (HCV) infections progress to chronicity and progressive liver damage. Alpha interferon (IFN-α) antiviral therapy achieves the highest rate of success when IFN-α is administered early during the acute phase, but the underlying mechanisms are unknown. We used a...

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Detalhes bibliográficos
Main Authors: Badr, Gamal, Bédard, Nathalie, Abdel-Hakeem, Mohamed S., Trautmann, Lydie, Willems, Bernard, Villeneuve, Jean-Pierre, Haddad, Elias K., Sékaly, Rafick P., Bruneau, Julie, Shoukry, Naglaa H.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Microbiology (ASM) 2008
Assuntos:
Pathogenesis and Immunity
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2566289/
https://ncbi.nlm.nih.gov/pubmed/18667516
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.01083-08
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