Distinct modes of SMAD2 chromatin binding and remodeling shape the transcriptional response to NODAL/Activin signaling

NODAL/Activin signaling orchestrates key processes during embryonic development via SMAD2. How SMAD2 activates programs of gene expression that are modulated over time however, is not known. Here we delineate the sequence of events that occur from SMAD2 binding to transcriptional activation, and the...

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Vydáno v:eLife
Hlavní autoři: Coda, Davide M, Gaarenstroom, Tessa, East, Philip, Patel, Harshil, Miller, Daniel S J, Lobley, Anna, Matthews, Nik, Stewart, Aengus, Hill, Caroline S
Médium: Artigo
Jazyk:Inglês
Vydáno: eLife Sciences Publications, Ltd 2017
Témata:
Genes and Chromosomes
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC5305219/
https://ncbi.nlm.nih.gov/pubmed/28191871
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.7554/eLife.22474
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