Transient Dysregulation of Dopamine Signaling in a Developing Drosophila Arousal Circuit Permanently Impairs Behavioral Responsiveness in Adults

The dopamine ontogeny hypothesis for schizophrenia proposes that transient dysregulation of the dopaminergic system during brain development increases the likelihood of this disorder in adulthood. To test this hypothesis in a high-throughput animal model, we have transiently manipulated dopamine sig...

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Détails bibliographiques
Publié dans:Front Psychiatry
Auteurs principaux: Ferguson, Lachlan, Petty, Alice, Rohrscheib, Chelsie, Troup, Michael, Kirszenblat, Leonie, Eyles, Darryl W., van Swinderen, Bruno
Format: Artigo
Langue:Inglês
Publié: Frontiers Media S.A. 2017
Sujets:
Psychiatry
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC5304146/
https://ncbi.nlm.nih.gov/pubmed/28243212
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fpsyt.2017.00022
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