Convergence of Eicosanoid and Integrin Biology: Role of Src in 12-LOX activation

12-Lipoxygenase (12-LOX) metabolizes arachidonic acid to 12(S)-hydroxyeicosatetraenoic acid, or 12(S)-HETE, a proinflammatory bioactive lipid implicated in tumor angiogenesis, growth, and metastasis. The mechanisms underlying 12-LOX-mediated signaling in cancer progression are still ill-defined. In...

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Bibliografiske detaljer
Udgivet i:Exp Cell Res
Main Authors: Dilly, Ashok-kumar, Tang, Keqin, Guo, Yande, Joshi, Sangeeta, Ekambaram, Prasanna, Maddipati, Krishna Rao, Cai, Yinlong, Tucker, Stephanie C., Honn, Kenneth V.
Format: Artigo
Sprog:Inglês
Udgivet: 2016
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5303182/
https://ncbi.nlm.nih.gov/pubmed/28011194
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.yexcr.2016.12.011
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